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Ask your Healthcare Provider
about ZUBSOLV!
What is ZUBSOLV (buprenorphine and naloxone) sublingual tablet (CIII)?
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ZUBSOLV is a prescription medicine used to treat opioid addiction in adults and is part of a complete treatment program that also includes counseling and behavioral therapy.
Important Safety Information
What is the most important information I should know about ZUBSOLV?
- ZUBSOLV contains an opioid called buprenorphine that can cause serious and life-threatening breathing problems, especially if you take or use certain other medicines or drugs. Get emergency help right away if you feel faint, feel dizzy, are confused, feel sleepy or uncoordinated, have blurred vision, have slurred speech, are breathing slower than normal, cannot think well or clearly.
What is ZUBSOLV® (buprenorphine and naloxone) sublingual tablet (CIII)?
ZUBSOLV is a prescription medicine used to treat opioid addiction in adults and is part of a complete treatment program that also includes counseling and behavioral therapy.
Important Safety Information
What is the most important information I should know about ZUBSOLV?
- ZUBSOLV contains an opioid called buprenorphine that can cause serious and life-threatening breathing problems, especially if you take or use certain other medicines or drugs. Get emergency help right away if you feel faint, feel dizzy, are confused, feel sleepy or uncoordinated, have blurred vision, have slurred speech, are breathing slower than normal, cannot think well or clearly.
- Ask your healthcare provider about medications like naloxone or nalmefene that can be used in an emergency to reverse opioid overdose, including accidental use of ZUBSOLV by a child. If naloxone or nalmefene is given, you must still call 911 or get emergency medical help right away to treat an overdose or accidental use of an opioid. In an emergency, have family members tell emergency department staff that you are physically dependent on an opioid and being treated with ZUBSOLV.
- Do not take ZUBSOLV with certain medicines. Taking ZUBSOLV with other opioid medicines, benzodiazepines, gabapentinoids (gabapentin or pregabalin), alcohol, or other central nervous system depressants (including street drugs) can cause severe drowsiness, decreased awareness, breathing problems, coma, and death.
- Do not inject (“shoot up”) ZUBSOLV. Injecting ZUBSOLV may cause life-threatening infections, other serious health problems, and sudden serious withdrawal symptoms such as pain, cramps, vomiting, diarrhea, anxiety, sleep problems, and cravings.
- Do not switch from ZUBSOLV to other medicines that contain buprenorphine without talking with your healthcare provider. The amount of buprenorphine in a dose of ZUBSOLV is not the same as other medicines that contain buprenorphine.
- Do not stop taking ZUBSOLV suddenly. You could become sick and have withdrawal symptoms because your body has become used to the medicine (physical dependence). Physical dependence is not the same as drug addiction.
- Never give anyone else your ZUBSOLV. They could die from taking it. Selling or giving away ZUBSOLV is against the law. Store ZUBSOLV securely, out of sight and reach of children, and in a location not accessible by others, including visitors to the home.
Who should not take ZUBSOLV?
- Do not take ZUBSOLV if you are allergic to buprenorphine or naloxone.
What should I tell my healthcare provider before taking ZUBSOLV?
Before taking ZUBSOLV, tell your healthcare provider:
- About all of your medical conditions, including if you have trouble breathing or lung problems, a curve in your spine that affects your breathing, Addison’s disease, an enlarged prostate (men), problems urinating, liver, kidney, or gallbladder problems, alcoholism, a head injury or brain problem, mental health problems, adrenal gland or thyroid gland problems, tooth problems, including a history of cavities.
- All of the medicines you take, including prescription and over-the-counter medicines, vitamins, or herbal supplements.
- If you are pregnant or plan to become pregnant. If you take ZUBSOLV while pregnant, your baby may have symptoms of opioid withdrawal at birth that could be life-threatening if not recognized and treated.
- If you are breastfeeding. ZUBSOLV can pass into your breast milk and harm your baby. Talk to your healthcare provider about the best way to feed your baby if you take ZUBSOLV. Monitor your baby for increased drowsiness and breathing problems if you breastfeed during treatment with ZUBSOLV.
What are the possible side effects of ZUBSOLV?
ZUBSOLV can cause serious side effects, including:
- Trouble breathing. Taking ZUBSOLV with other opioid medicines, benzodiazepines, gabapentinoids (gabapentin or pregabalin), alcohol, or other central nervous system depressants can cause breathing problems that can lead to coma or death.
- Sleepiness, dizziness, and problems with coordination.
- Physical dependence or abuse.
- Liver problems. Call your healthcare provider right away if you notice any of these symptoms: your skin or the white part of your eyes turns yellow (jaundice), dark or “tea-colored” urine, light colored stools (bowel movements), loss of appetite, pain, aching, or tenderness on the right side of your stomach area, nausea. Your healthcare provider should do blood tests to check the liver before you start and while you are taking ZUBSOLV.
- Allergic reaction. Call your healthcare provider or get emergency help right away if you have a rash, hives, swelling of your face, wheezing, low blood pressure or loss of consciousness.
- Opioid withdrawal. Call your healthcare provider right away if you get any of these symptoms: shaking, sweating more than normal, feeling hot or cold more than normal, runny nose, watery eyes, goose bumps, diarrhea, vomiting, muscle aches.
- Decrease in blood pressure. You may feel dizzy if you get up too fast from sitting or lying down.
- The most common side effects of ZUBSOLV include: headache, nausea, vomiting, constipation, pain, increased sweating, decrease in sleep (insomnia).
- ZUBSOLV may affect fertility in males and females. Talk to your healthcare provider if this is a concern for you.
- These are not all the possible side effects of ZUBSOLV.
For additional safety information, click here for Prescribing Information and Medication Guide and discuss with your healthcare provider.
To report negative side effects associated with taking ZUBSOLV, please call 1-888-982-7658. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
This site is intended for residents of the United States.
ZUBSOLV is a licensed trademark of Dexcel Pharma USA.
Other trademarks, registered or otherwise, are the property of their respective owner(s).
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© 2026 Dexcel Pharma USA. All rights reserved.